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There has been a flood of new drugs on the black market since 2008. These substances, also known as “designer drugs,” “research chemicals,” or “novel psychoactive substances” (NPS), are used for their pharmacological effects, which are frequently comparable to those of more well-known drugs like heroin or ecstasy. In some cases, users are specifically looking for these new chemicals, while in others, they are just buying what they think is their usual drug from a dealer, but the product isn’t what it says it is. It is possible for laboratories to be prepared with validated tests for detecting new compounds in biological specimens thanks to the implementation of national and international systems that monitor the appearance of new compounds.

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Synthetic cannabinoids, novel opioids, novel benzodiazepines, stimulants, and hallucinogens are the most common types of NPS. The compounds may be drugs that were initially synthesized for research purposes in the search for new therapeutic agents, such as the designer opioid U47700 and the synthetic cannabinoid JWH-018. Others, like etizolam, are substances that are utilized in other nations but are uncommon in the United States. Some are synthetic drugs designed to circumvent legal restrictions. Research chemicals (RCs) are substances that are used recreationally by people seeking to alter their moods and get high.1 Research chemicals (RCs) are dangerous and do not have a legitimate or legal purpose for the general public. In every instance, these compounds present a unique challenge to forensic toxicology laboratories, which must quickly develop and validate analytical methods for the identification and quantification in biological matrices. Research chemicals are not chemicals used in scientific research, despite their name. Research chemicals can be extremely hazardous and are poorly understood in the context of substance abuse. Even though MDMA is not a chemical used in research, some of these substances have effects similar to those of MDMA when ingested. This scientific article explains research chemicals in greater detail.

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For the purposes of legal and regulatory regulations, research chemicals are frequently categorized as synthetic drugs. The term “synthetics” refers to a broad category of drugs that includes “ecstasy” (MDMA), “ketamine,” “bath salts,” and “synthetic cannabinoids” (Spice and K2). Because they are all produced in laboratories and many of them have legal analogues that were developed specifically to circumvent drug enforcement laws, many agencies refer to these drugs as new psychoactive substances (NPS). The following warning label is frequently found on these products’ packaging: not for consumption by humans.
Currently, specific molecules or chemical structures are prohibited by state and federal drug laws in the United States; however, research chemical manufacturers attempt to circumvent these laws by altering the drug’s structure as new laws are enacted. This makes research chemicals even more dangerous and unpredictable; The fact that one batch produced a high resembling that of a stimulant does not guarantee that the next batch will. In 2018, the UN Office on Drugs and Crime stated that the majority of NPS reported worldwide were either slightly altered versions of previously reported chemicals or a combination of previously reported NPS. As of 2017, 478 distinct NPS were found to be available as pharmaceuticals.
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