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Infertility in women is treated with this medication. It works by encouraging an increase in the amount of hormones that help an egg grow and hatch (ovulation).Women with primary pituitary or ovarian failure, in which the ovaries no longer produce eggs as they should, should not take this medication.
To get the most out of clomiphene, you must take it exactly as your doctor tells you to. It is essential to strictly adhere to your dosing schedule.
Your medical condition and response to therapy determine your dosage. Do not take it more frequently or for a longer period of time than your doctor has advised. This medication should not be used for a long time and should only be used for six cycles.
For best results, you may be instructed to record your body temperature, take ovulation tests, and time sexual activity correctly. If you have any questions, talk to your doctor.
Additionally, fibrocystic breasts, menstrual abnormalities, and persistent breast milk production are all conditions that can be treated with clomiphene. Discuss the potential side effects of taking this medication for your condition with your doctor.
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There may be other uses for this medication; For more information, consult your physician or pharmacist.
The monthly process by which the female reproductive system produces a mature egg is known as ovulation. The pituitary gland in the brain releases two hormones during ovulation: luteinizing hormone (LH) and follicle stimulating hormone (FSH). These hormones are collectively referred to as gonadotropins. The pituitary gland sends FSH as a “messenger” to the ovaries to encourage the growth of follicles, each of which will contain one egg. Ovulation, or the release of the egg, is initiated by LH.
Estradiol is produced by the ovarian follicles during the first half of the menstrual cycle. Estradiol stimulates the growth of the uterine lining (endometrium) and the production of the watery cervical mucus known as “raw egg white” that aids the sperm in swimming up through the uterus to the fallopian tubes. The pituitary gland releases a surge of the LH hormone about two weeks later, which sets off ovulation. The follicle, which is now referred to as the corpus luteum, begins producing the hormone progesterone at this point. This hormone thickens the lining of the uterus in preparation for a possible pregnancy. If a pregnancy has not occurred within two weeks of ovulation, the corpus luteum stops producing progesterone, the endometrium sloughs off, and menstrual bleeding begins.
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The body’s ability to ovulate can be hampered by a variety of conditions. Medications that encourage the ovarian follicles to produce multiple eggs during a single cycle are one of the primary approaches to this problem. Clomiphene Citrate (Clomid or Serophene) and gonadotropins (Follistim, Menopur, Bravelle, and Gonal-F) are the two most widely used fertility medications.
Clomiphene is a synthetic chemical that raises pituitary FSH levels when taken orally and binds to estrogen receptors in the brain (see below). Gonadotropins, which are administered intravenously and are analogous to the human protein hormones FSH and LH, directly stimulate the ovaries rather than the pituitary gland.
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