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Nandrolone phenylpropionate (NPP), or androgen phenpropionate, oversubscribed below the name nandrolone among others, is Associate in Nursing androgenic hormone and steroid hormone (AAS) medication that has been used primarily within the treatment of carcinoma and pathology in girls. it’s given by injection into muscle once each week.[3] though it absolutely was wide employed in the past, the drug has largely been interrupted and thus is currently largely now not offered.

Side effects of NPP embrace symptoms of virilization like inflammatory disease, exaggerated hair growth, voice changes, and exaggerated physical attraction.  The drug could be a artificial androgenic hormone Associate in Nursingd steroid hormone and thus is an agonist of the androgenic hormone receptor (AR), the biological target of androgens like androgenic hormone and dihydrotestosterone (DHT). it’s robust anabolic effects and weak steroid hormone effects, that provides it a light facet impact profile and create it particularly appropriate to be used in girls and kids NPP could be a androgen organic compound and a long prodrug of androgen within the body.

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NPP was 1st delineate in 1957 and was introduced for medical use in 1959. it absolutely was the primary androgen organic compound to be introduced, followed by androgen decanoate in 1962, and has been one among the foremost wide used androgen esters. but, in additional recent times, the drug has been mostly outmoded by androgen decanoate, that is longer-acting and a lot of convenient to use. additionally to its medical use, NPP is employed to boost physique and performance. The drug could be a drug in several countries so non-medical use is mostly illicit.

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The effects of 3 doses (1,4 Associate in Nursingd ten mg/kgbody weight) of an steroid hormone, androgen phenylpropionate (NPP), on weight and composition, and muscle macromolecule metabolism were investigated in feminine rats. Daily injections of one mg/kg of NPP for ten days caused a big increase in weight gain that was related to a rise in body macromolecule (9%) while not touching body fat. At higher doses this impact on weight was attenuated, leading to no modification in weight at ten mg/kg. but body macromolecule content was still exaggerated (9%) whereas body fat content was considerably reduced (32%). NPP didn’t have an effect on metabolizable energy intake at any dose tested. Body energy gain and gross energetic potency were each considerably reduced in animals treated with a dose of ten mg/ kilo. The mass and macromolecule content of gastrocnemius were considerably exaggerated in animals injected with NPP the least bit doses. Muscle macromolecule synthesis measured in vivo was conjointly considerably stirred at one and four mg/kg however wasn’t affected at ten mg/kg. These information ensure Associate in Nursing anabolic action of NPP and counsel extremely dose-dependent effects on alternative parameters like weight, fat deposition and muscle macromolecule synthesis.

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