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The first SARM was Andarine, more commonly referred to as S4. It was created to treat osteoporosis, benign prostate hypertrophy, and muscle wasting. Even though this molecule does not look like a steroid, scientists found that it selectively activates androgen receptors in the human body, favoring those in skeletal muscle, bone, and connective tissue over those in the prostate and scalp. As a result, a lot of research has been done on molecules that only activate the androgen receptor (AR). S4’s higher affinity for binding to these androgen receptors is how it achieves selectivity.

S4 administration results in dose-dependent improvements in bone health in rats, according to studies. Bone mineral density, lean mass, and body composition all showed significant improvements with 1.6 mg/kg bodyweight in one study. Additionally, significant increases in muscle mass were observed at 3mg/kg/day. Both groups showed improvements in whole body and trabecular bone mineral density, cortical content, and decreased body fat in the ovariectomized rat model of osteoporosis after receiving 3 and 10 mg/kg/day for eight weeks. S4 was found to be more anabolic than DHT in primary culture of osteoprogenitor cells from bone marrow, confirming its anabolic potential in bone tissue.

In addition, studies have shown that 5 mg/kg finasteride has a similar effect on prostate weight loss without affecting levator ani muscles—an indicator of relative androgenicity. SARMs may hold the key to these kinds of benefits in situations of unwanted prostate growth, whereas SERMs are ideal candidates for reducing breast tissue and the spread of breast cancer.

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Despite the fact that anecdotal reports rate S4 as having fewer side effects than other SARMs, it does have one effect at higher doses that is unique to other compounds: a temporary slight yellowing of the vision and a decrease in night vision.

Andarine (GTx-007, S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc. for the treatment of muscle wasting, osteoporosis, and benign prostatic hypertrophy. It uses the non-steroidal androgen antagonist bicalutamide as its lead compound.

Andarine is a partial agonist of Androgen receptors that can be taken orally. Compared to other SARMs, its anabolic and androgen effects are weaker. Andarine was found to reduce prostate weight in an animal model of benign prostatic hypertrophy in a manner that was comparable to that of finasteride, but it did so without causing muscle loss or other anti-androgen effects.

This suggests that it can competitively block dihydrotestostero’s binding to its receptor targets in the prostate gland. However, its partial agonist effects at Androg receptors prevent the side effects of anti-Androgen medications that are typically used to treat BPH.

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For 12 to 16 weeks, take 50 to 75 milligrams of S-4 five days a week. S-4 does not need to be taken three times throughout the day, as previously stated;  However, if you prefer to take it this way, you should take a dose of 25 milligrams, or about half a milliliter, once with each of your three main meals.

S-4 does indeed exhibit a point of diminishing returns, as previously stated.  As a result, taking S-4 at doses above 75 milligrams or for more than 16 weeks will not increase muscle mass. There won’t be an expansion in secondary effects either, yet you will be risking AR desensitization and definitely squandering your item.

The researcher will not be able to experience all of the product’s benefits if they take S-4 for less than six to eight weeks.

50 mg once every 6 to 8 weeks is the recommended dosage for cutting. It should be used every day, with two days off in between. Changes in vision may occur if S4 is taken every day for the duration of the cycle.